Advanced Research Core
Apply Yourself in Applied Research
In our Advanced Research Core program, you can participate in applications-oriented, graduate-level research projects with the NYIT College of Osteopathic Medicine (NYITCOM). Work under the mentorship of a NYITCOM faculty member as you provide technical assistance and intellectual input.
Create Knowledge, Make a Difference
If you’re ready to demonstrate high levels of commitment and dedication, the Advanced Research Core (ARC) program is a pathway to a unique educational experience.
Work with faculty at the NYIT College of Osteopathic Medicine (NYITCOM) to support their medical research projects. Be part of the discovery process and actually create knowledge as you help unlock new findings. Work as part of a team while performing basic or applied research. Many ARC projects are published in peer-reviewed journals and presented at national conferences.
Expectations & Opportunities
You will be expected to contribute at least eight hours per week toward your ARC project. In addition, NYITCOM faculty may have specific requirements for their research. You will also have the opportunity to participate in NYIT’s Symposium of University Research and Creative Expression (SOURCE), and present findings to member of the NYIT community.
Our research is on epithelial physiology, with a particular emphasis on renal physiology, and has covered multiple areas including basic epithelial transport physiology, cystic fibrosis, polycystic kidney disease, and, most recently, acute kidney injury.
Our research focuses on the cellular and molecular mechanisms that underlie acquired heart disease, cardiac hypertrophy, and heart failure. Current research in the laboratory is addressing three questions: why diabetic patients are more susceptible to heart failure, how a widely used anti-cancer drug may contribute to heart failure, and how caloric restriction can protect the heart. Central to each question is the role of mitochondria. Using both cell culture and genetically modified animal models, we are investigating the molecular underpinnings and coordination of mitochondrial quality control processes including mitochondrial biogenesis, fission/fusion, and mitophagy, and their roles in cardiac hypertrophy and heart failure.
We are working to understand the mechanisms by which diabetes leads to microvascular and macrovascular complications. The primary goal of our lab is to better understand how diabetic conditions alter key molecular mediators that are essential for maintaining vascular integrity. These studies focus on identifying potential targets that will alleviate diabetes-induced vascular complications such as atherosclerosis, coronary disease, and hypertension.
Gap junction channels are protein tubes that directly connect the cytoplasm of adjacent cells, and are required for development and function of all human organs. We use cell biology and computational modeling approaches to understand how the structural configurations of gap junctions produces normal tissue function. We will process and analyze microscopy data produced through high-resolution imaging of cells engineered to express fluorescent protein-tagged gap junction components. We will use resulting high-dimensionality image data to discover new information about the arrangement and mobility of gap junction components. We will also use the results of our analysis to build a spatially realistic computational model of a gap junction connection to allow new hypotheses to be developed regarding the effects of structural changes that occur to gap junctions as a result of disease-relevant mutations. We will test and model the form of gap junction that occurs in the brain. Gap junctions are a major type of connection between brain cells and major changes to connectivity by gap junctions are observed in every major neurological disease- including multiple sclerosis, Alzheimer’s and Major Depressive Disorder. The results of our research are expected to produce incremental but important contributions to our understanding of how the brain functions in health and disease. The ability to work independently to learn new computer programs and solve detailed technical challenges is essential for computational biology focused projects such as this one. Students should be capable of working with programs including Excel, Word, and Powerpoint. Students should also have some experience in coding. Minor experience in any coding language is good but Python or C# experience would be a major plus. Experience with 3D modeling programs such as Blender, Maya, 3DSMax, or Solidworks would be a huge plus as well.
Our lab is interested in the development and evolution of brains and skulls of archosaur reptiles (alligators, dinosaurs, birds), lizards, and snakes. Projects include constructing high-resolution 3-D models of brains and skulls of alligators and birds from micro-CT scan data, ecological drivers of hyper-diverse skull shapes of lizards and snakes, and statistical analysis of protein structures to identify rapidly-evolving regions. We are also developing an app that converts temporal ecological and evolutionary data into music.
Knowledge of the genetic, molecular and cellular mechanisms of normal brain development is pivotal in understanding childhood brain tumors. Our lab is interested in signaling pathways and transcriptional regulation in brain development and pediatric brain tumors. Our research focuses on the interaction between rhombic lip and roof plate and its implication in tumors that arise from these tissue origins. We use cellular and genetic approaches to develop accurate pre-clinical models to understand mechanisms of tumorigenesis, develop innovative diagnostic strategies, and discover novel therapeutic targets for developing safer and more effective therapies.
- Grade of B or higher in General Biology I & II and General Chemistry I & II
- Demonstrated interest and dedication to research
- Preferred majors include life sciences, biotechnology, physical therapy, physician assistant studies, occupational therapy, and nursing
Navin Pokala, Ph.D.
Department of Life Sciences
Kurt Amsler, Ph.D.
Professor and Associate Dean for Research
Department of Biomedical Sciences