Advanced Research Core

You can participate in applications-oriented, graduate-level research projects with the NYIT College of Osteopathic Medicine (NYITCOM). Work under the mentorship of a NYITCOM faculty member as you provide technical assistance and intellectual input on a biomedical research project. Be part of the discovery process and create knowledge as you help unlock new findings. Work as part of a team while performing basic or applied research. Many projects are published in peer-reviewed journals and presented at national conferences.

Expectations & Opportunities

You will be expected to contribute at least eight hours per week toward your project. In addition, NYITCOM faculty may have specific requirements for their research. You will also have the opportunity to participate in New York Institute of Technology’s Symposium of University Research and Creative Expression (SOURCE), and present findings to member of the New York Tech community. Research must be performed in a manner consistent with university COVID-19 guidelines.

Eligibility Requirements

  • Grade of B or higher in General Biology I & II and General Chemistry I & II
  • Demonstrated interest and dedication to research.
  • Open only to current New York Tech students.

Faculty Research

Professor Randy Stout

The lab of Dr. Randy Stout in the Department of Biomedical Sciences is looking for a student to join our cellular neuroscience group doing microscopy-based research on gap junctions and extracellular vesicles of astrocytes and tanycytes. The student who joins our group will be working part-time remotely with super-resolution 3D image data to analyze nanoscale morphological structures. The general goal of our research is to understand how the brain works under healthy conditions and in neurodevelopmental disorders such as autism.

Professor Jerry Zhao

Research in the Jerry Zhao Lab is focused on neurodegenerative disorders, neurodevelopmental disorders, and neuroepigenetics. We are particularly interested in the role of heparan sulfate and long genes in brain health and disease. (1) Heparan sulfate is a glycosaminoglycan that covers the surface of all human cells. Heparan sulfate plays an important role in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease. (2) Long genes (> 100 kilobases) are highly expressed in the brain and show unique genomic and epigenomic features. Long genes are associated with neurodevelopmental disorders such as autism and Rett syndrome. (3) Lastly, we are also actively developing Machine Learning algorithms to integrate biomedical and clinical data. The lab utilizes multidisciplinary approaches including animal disease models, mouse genetics, neuroscience, genomics, bioinformatics, and molecular biology."

Professor Gonzalo Otazu

Current machine learning algorithms fall short from the capability of nervous system to adapt to novel situations. We are interested in applying a new algorithm based on neuroscience research for superresolution imaging. Superresolution microscopy allows for the detection of single molecules at a higher resolution than the one given by the diffraction limit. Current algorithms cannot deal very well with thick samples as the single molecule image is superimposed with a background that affects the localization. Sensory processing at low SNR is a task at which the nervous system excels. By using the brain-derived algorithm we expect to improve on current algorithms. Python and/or Matlab experience is required.

Professor Milan Toma

The work includes mostly processing surface files of geometries extracted from medical images of human body parts, which can be done at home.

Professor Weikang Cai

Astrocytes are the most abundant glial cells in the brain. They respond to external signals to modulate brain metabolism, neuronal activity, and behavior. The main research interest of our laboratory is to understand how these astrocyte-originated responses may affect the progression of several neurological disorders, including depression, and neurodegenerative diseases. The students are expected to assist on data acquisition and analysis from both cell and animal studies.

Professor M.Alicia Carrillo Sepulveda

Our laboratory is focused on understanding how obesity contributes to blood vessels damage which results in vascular complications, including hypertension. For that, we have studied how different fat/adipose tissue (brown fat, white fat, beige fat) surrounding arteries can affect vascular function We also study if sex-differences play a role in obesity-related hypertension. Our research uses preclinical mice model of obesity, in vivo study of arterial stiffness, arterial blood pressure, and metabolic parameters, ex vivo vascular reactivity studies, in vitro primary vascular cells cultures and molecular approaches.

Professor Satoru Kobayashi

Our research mission is to save heart muscle cells (cardiomyocytes) from diabetic stress. Diabetes kills two out of three patients by causing heart disease. It’s not a sudden death. It is a slow death process. The fatal stress is creeping on your heart before you know it. Diabetes gradually turns up the heat, but, your heart muscle cells don’t know they’re dying. What we found is that too much sugar injures lysosomes. Lysosomes are the defense force in your heart cells. They are in charge of breaking down and removing damaged debris inside the cells for your health. High glucose, the sugar, is a moderate but still fatal stress to the cells. Our cell defense system is compromised and fails to respond to this sneaking stress. The project is to test some potential drugs if they can repair/protect the lysosomes so that they can stay functional to protect your heart muscle cells.

Professor Olga Savinova

The project investigates the effect of plasma alkaline phosphatase on vascular calcification in an animal modal of atherosclerosis.

Professor Haotian Zhao

Brain cancers are the most common solid tumors in children and the leading cause of death from childhood cancers. Little progress has been made in the management of pediatric brain cancers, for which standard treatment regimens leave survivors with long-term deleterious side effects. Greater knowledge of how proliferation of brain cells is regulated, and how its disruption contributes to childhood brain cancers will help to develop therapies that specifically target tumor growth without damaging the developing brain. The choroid plexus (CP) in each brain ventricle consists of a fibro-vascular core encapsulated by epithelium that differentiates from neuroepithelial progenitors. Though neoplasms of the CP are rare, they predominantly occur in childhood and comprise up to 20% of brain tumors in children under one year of age.

CP papilloma is generally benign, whereas malignant CP carcinoma (CPC) is highly lethal with few treatment options. CPC typically responds poorly to treatment and often returns and metastasizes. Despite the dire consequences, knowledge of the molecular and cellular underpinnings of CPC is limited. Our recent studies show that molecular and cellular mechanisms of CP differentiation are critically involved in CPC. The project will examine the role of microRNAs in CP differentiation and tumorigenesis. An innovative single molecule technology will be used to evaluate microRNAs as potential biomarkers of CPC for non-invasive diagnosis and monitoring. The project will gain significant insights into CPC and provide a platform for the evaluation of novel diagnostic and therapeutic strategies through enabling technology for cancer research and scientific discovery.

ARC Application Spring 2022

Contact Us

Navin Pokala, Ph.D.
Assistant Professor
Department of Biological and Chemical Sciences
516.686.7771
navin.pokala@nyit.edu

Kurt Amsler, Ph.D.
Professor and Associate Dean for Research
Department of Biomedical Sciences
kamsler@nyit.edu