Advanced Research Core
Apply Yourself In Applied Research
In our Advanced Research Core program, you can participate in applications-oriented, graduate-level research projects with the NYIT College of Osteopathic Medicine (NYITCOM). Work under the mentorship of a NYITCOM faculty member as you provide technical assistance and intellectual input.
Create Knowledge, Make A Difference
If you’re ready to demonstrate high levels of commitment and dedication, the Advanced Research Core (ARC) program is a pathway to a unique educational experience. Work with faculty at the NYIT College of Osteopathic Medicine (NYITCOM) to support their medical research projects. Be part of the discovery process and actually create knowledge as you help unlock new findings. Work as part of a team while performing basic or applied research. Many ARC projects are published in peer-reviewed journals and presented at national conferences.
Expectations & Opportunities
You will be expected to contribute at least eight hours per week toward your ARC project. In addition, NYITCOM faculty may have specific requirements for their research. You will also have the opportunity to participate in New York Institute of Technology’s Symposium of University Research and Creative Expression (SOURCE), and present findings to member of the NYIT community.
- Grade of B or higher in General Biology I & II and General Chemistry I & II
- Demonstrated interest and dedication to research
- Preferred majors include life sciences, biotechnology, physical therapy, physician assistant studies, occupational therapy, and nursing
Replace the material in the Faculty Research section w/ the following:
Michael C. Granatosky
My research explores locomotor biomechanics in an evolutionary framework to address the overarching question: How to build a quadruped? Quadrupedal locomotion is an incredibly complex form of movement that requires animals to coordinate multiple oscillating anatomical regions through space and time. Furthermore, the neuromuscular substrates for quadrupedal movement are ancient and represent the primitive condition in which all other tetrapod locomotor modes are based. As such, it is impossible to explore important evolutionary events such as the fin-to-limb transition, the advent of flight, or the origins of bipedalism without first considering quadrupedal gait mechanics.
With these considerations in mind, the question of “How to build a quadruped?” becomes a fascinating area of inquiry that requires a collaborative and interdisciplinary investigative approach. My research addresses this broad question through a neontological perspective using living animal models. Current projects in my lab include: using “walking” fish to investigate neuromuscular evolution and energetic costs during the fin-to-limb transition; exploring the importance of proprioceptive sensory information in dictating locomotor performance; and utilizing information gleaned from living animals to develop biomimetic machines.
Knowledge of the genetic, molecular and cellular mechanisms of normal brain development is pivotal in understanding childhood brain tumors. Our lab is interested in signaling pathways and transcriptional regulation in brain development and pediatric brain tumors. Our research focuses on the interaction between rhombic lip and roof plate and its implication in tumors that arise from these tissue origins. We use cellular and genetic approaches to develop accurate pre-clinical models to understand mechanisms of tumorigenesis, develop innovative diagnostic strategies, and discover novel therapeutic targets for developing safer and more effective therapies.
We are studying the role of autonomic nervous system on cardiac arrhythmias in heart failure. We are also studying Holiday Heart Syndrome (cardiac arrhythmias induced by binge drinking). Students will be working with animals (rats) and learning cell culture techniques and immunostaining. In addition, students will likely learn imaging approaches and Western blotting.
Looking for students eager to learn X-ray CT imaging data processing, statistical shape analysis (geometric morphometrics), and some coding (if one wishes). Students will be engaged in constructing high-resolution 3-D models of brains and skulls across the avian diversity from micro-CT scan data. The project will also involve performing high-density statistical shape analysis to visualize, evaluate, and model the correlated shape changes occurring between the brain and skull throughout development in these groups. A student, preferably with music background (but not necessary), will develop a new application for converting temporal data (e.g., species diversity through time) into music to provide a novel modality for appreciating and understanding scientific data. I envision the project leading to a publication, as well as entry into several “Art & Science” competitions.
I can accommodate one student to assist me with an investigation of the tooth wear patterns and paleodiets of extinct populations on tapirs that live in North America 4.8 million years ago. We will be performing surface texture analysis of dental wear surfaces of fossil tapir teeth collected from the Gray fossil site in Tennessee to test hypotheses about the diets and paleoecology of tapirs in North America. Results will be compared to fossilized stomach contents and the tooth wear patterns of modern tapirs from Asia and South America. The role of the student will be to scan tooth surfaces on the optical profilometer in the Anatomy Department’s Data Visualization Center with the possibility of visiting the American Museum of Natural History collections in the late spring or early summer to collect comparative samples.
Yingtao (Jerry) Zhao
High-throughput sequencing technologies have revolutionized biomedical research in the past decade and have led to an explosion of omics data. However, it’s still a big challenge to interpret these data and use them to help patients. My lab leverages genomics, bioinformatics, and machine learning to understand human mental disorders. Requirement: interest in genomics and computational biology
New York Institute of Technology undergraduates will be involved in one of several projects that are ongoing in the lab regarding anatomical changes that take place in the brain during development. These studies employ anatomical methods such as immunohistochemistry in order to visualize unique neuronal types and their synaptic connections in mouse models. New York Tech students working in the lab will learn genotyping as well as histological techniques including tissue sectioning, staining, photomicroscopy, and data analysis. Students who work for several semesters/years may have an opportunity to learn additional techniques such as animal perfusion, brain harvesting, surgery, etc.
In addition to learning lab techniques, students will learn the basics of experimental design, hypothesis testing, neuronal development, nervous system disorders, and will get an introduction to reading journal articles. Finally students will learn how to work independently as well as part of a larger team. No prior research experience or particular skills are required and 6 hrs per week commitment is expected.
Gonzalo Otazu Aldana
Autism spectrum disorders (ASD) presents with sensory deficits where patients have difficulties in processing information in the presence of multiple stimuli. We are working now on understanding the circuits that permits to process information in the presence of multiple stimuli and how these circuits might be affected in ASD. We have developed an olfactory behavioral paradigm that neurotypical mice are able to solve. However, CNTNAP2 knockout mice, a mouse model of ASD, cannot solve. We want to extend the work to other mouse models of autism using optogenetics, imaging, and behavioral measurements. We have preliminary results that indicate that we can revert some of these symptoms using a pharmacological approach.
Our group is studying the mechanism by which large solutes pass between epithelial cell sheets in epithelial cell sheets moving from one fluid compartment to another (paracellular pathway). While much is now known about how small ions and water cross epithelial cell sheets via the paracellular pathway, relatively little is known about how macromolecules cross these barriers. Our studies use a combination of population-based flux measurements of large solutes and state-of-the-art imaging techniques, including super-resolution confocal microscopy and single molecule tracking, to examine the structures through which the macromolecules pass at the single molecule level. This research has implications for basic epithelial physiology, epithelial pathophysiology including carcinoma, and drug delivery.
Navin Pokala, Ph.D.
Department of Biological and Chemical Sciences
Kurt Amsler, Ph.D.
Professor and Associate Dean for Research
Department of Biomedical Sciences