Staff & Faculty Directory
Natarajan Ganesan
Assistant Professor; Research, College of Osteopathic Medicine
Assistant Director, Educational Research; Research, College of Osteopathic Medicine
Industry Credentials: Ph.D., M.B.A.
Expertise: Molecular Biophysics, Cancer Research, Bio-IT and Health-IT
Joined New York Tech: 2023
Natarajan Ganesan specializes in molecular biophysics, cancer research, and bioinformatics. Recently, Ganesan has been exploring the efficient utilization of large language models (LLMs) for data interpretation and summarization. Beyond his professional endeavors, he is passionate about amateur astronomy and astrophotography, exploring the wonders of the cosmos through observation and photography. Ganesan holds a Ph.D. in Biomedical Genetics from the University of Madras, Chennai, where he was honored with the prestigious DAAD fellowship. Additionally, he possesses an M.B.A. from Georgetown University.
Nucleic Acids Research:
The focus here lies in understanding DNA-ligand interactions, particularly their implications in anti-tumor activities. Ganesan utilizes various spectroscopic methods and bioanalytical instrumentation to shed light on their functional roles in cellular processes and disease mechanisms. Additionally, he has developed rapid methods for studying helix-coil transitions in DNA.
Cancer Research:
In this field, Ganesan delves into cancer genomics, analyzing somatic and germline variants using next-generation sequencing (NGS) data. His goal is to identify new biomarkers and therapeutic targets for precision medicine interventions.
Bioinformatics and Machine Learning:
Ganesan explores the integration of generative and large language models into existing knowledge bases to enhance data interpretation and summarization. He aims to provide more accurate insights into complex biological datasets.
Notable Contributions in Bio-IT:
Ganesan is proud to have developed Sequerome, a web-based Sequence Profiling Tool, and spearheaded CancerStop, a comprehensive reference portal for researchers, physicians, and the public. Both platforms have received recognition in prominent publications and press releases.
- “Will AI Hasten a Dystopian Healthcare Landscape?” (2023) BMJ Blog | Medical Humanities. BMJ, 29 August.
- Gopalaswamy R, Ganesan N, Velmurugan K, Aravindhan V, Subbian S. The Strange Case of BCG and COVID-19: The Verdict Is Still up in the Air. Vaccines (Basel). 2020 Oct 16;8(4):612. doi: 10.3390/vaccines8040612. PMID: 33081331; PMCID: PMC7711751.
- Ganesan N, Bennett NF, Velauthapillai M, Pattabiraman N, Squier R, Kalyanasundaram B. Web-based interface facilitating sequence-to-structure analysis of BLAST alignment reports. Biotechniques. 2005 Aug;39(2):186, 188. doi: 10.2144/05392BM05. PMID: 16116790.
- Ganesan N, Gadre AP, Paranjape M, Currie JF. Gold layer-based dual crosslinking procedure of glucose oxidase with ferrocene monocarboxylic acid provides a stable biosensor. Anal Biochem. 2005 Aug 1;343(1):188-91. doi: 10.1016/j.ab.2005.04.018. PMID: 15961058.
- Natarajan G, Malathi R, Holler E. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem Pharmacol. 1999 Nov 15;58(10):1625-9. doi: 10.1016/s0006-2952(99)00250-6. PMID: 10535754.
- Natarajan G, Malathi R, Holler E. Helix-coil transitions in DNA using a pH variation method: case of a melting paradox as a function of ionic strength. Anal Biochem. 1996 May 15;237(1):152-5. doi: 10.1006/abio.1996.0216. PMID: 8660553.
- BMSC 500: Enrichment topics in Biomedical Sciences
- BMSC 701: Research Methods
- BMSC 713: Research Seminar II
- Foundations of Osteopathic Medicine: Human Genetics I, II, III, and IV