Staff & Faculty Directory
Subhabrata Chaudhury
Assistant Professor; Biological & Chemical Sciences, College of Arts & Sciences
Education Credentials: Ph.D.
Expertise: Organic and Medicinal Chemistry
Joined New York Tech: 2023
Subhabrata Chaudhury is an organic and medicinal chemist whose research focuses on small-molecule drug discovery and synthetic methodology. His research program develops potent and selective inhibitors of pyruvate carboxylase (PC) as chemical probes for studying cancer cell metabolism and as leads for anticancer drug discovery. His group combines synthetic chemistry and structure-activity relationship studies with biochemical assays, permeability evaluation, and cell-based studies through collaborations within and beyond New York Tech. His other current projects involve robust Mitsunobu reaction strategies for the synthesis and diversification of bioactive molecules and small-molecule modulators targeting the helicase activity of human PIF1, a protein involved in genome stability. His previous work includes selective Hsp90-beta inhibitors and the scalable synthesis of estrogen receptor-beta agonists. He also has industrial medicinal chemistry experience as a team leader in oncology and virology.
Chaudhury received his M.Sc. in organic chemistry from the Indian Institute of Technology Kharagpur and his Ph.D. from Marquette University. He held research positions at the University of Kansas, the Medical College of Wisconsin, the University of Glasgow, and the University of Notre Dame, and later served as a visiting assistant professor at Marquette University. At New York Tech, he mentors graduate and undergraduate researchers and serves as a peer reviewer for chemistry and medicinal chemistry journals.
- Design, Synthesis, and Biological Evaluation of Potent and Selective Pyruvate Carboxylase (PC) Inhibitors for Studying Cancer Cell Metabolism
- Development of Robust Mitsunobu Reaction Strategies for the Synthesis and Diversification of Bioactive Molecules
- Development of Small-Molecule Modulators Targeting the Helicase Activity of Human PIF1
- Chaudhury, S.; D’Amico, T.; Blagg, B. S. J. “The Hsp90β Isoform: An Attractive Target for Drug Development.” Medicinal Research Reviews 2025, 45, 1452-1465.
- Chaudhury, S.; Wetzel, E. A.; Elmansy, M. F.; Hanson, A. H.; Brown-Ford, S.; Gleason, A.; Perera, I. S. K. L.; Sem, D. S.; Donaldson, W. A. “Analogues of the Potent and Selective ERβ Agonist trans-4-(4-Hydroxyphenyl)cyclohexanemethanol: Synthesis and Evaluation.” Synlett 2025, 36, 2960-2964.
- Chaudhury, S.; Thenakoon, D.; Wetzel, E. A.; Donaldson, W. A. “A Scalable, Chromatography-Free Synthesis of the Potent and Highly Selective ERβ Agonist EGX358.” Synthesis 2025, 57, 973-977.
- Schwabe, M. R.; Fleischer, A. W.; Kuehn, R. K.; Chaudhury, S.; York, J. M.; Sem, D. S.; Donaldson, W. A.; LaDu, M. J.; Frick, K. M. “The Novel Estrogen Receptor Beta Agonist EGX358 and APOE Genotype Influence Memory, Vasomotor, and Anxiety Outcomes in an Alzheimer’s Mouse Model.” Frontiers in Aging Neuroscience 2024, 16, 1477045.
- Schneider, N. O.; Gilreath, K.; Henriksen, N.; Donaldson, W. A.; Chaudhury, S.*; St. Maurice, M. “Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.” ACS Medicinal Chemistry Letters 2024, 15, 1088-1093. *Co-corresponding author.
- CHEM 210
- CHEM 250
- CHEM 420
- CHEM 440
- CHEM 944
- CHEM 945
- BIOL 493