Research: Biomedical Sciences

 

Brain Development and Neurodevelopmental Disorders

Studies the molecular and cellular mechanisms for normal brain development and the establishment of neuronal connections in order to understand neurodevelopmental disorders.

Principal Investigator: Raddy Ramos, Ph.D.

 

Vascular Calcification and Atherosclerosis

Studies the pathophysiological effects of vascular calcification in atherosclerosis; using pre-clinical models, examines if vascular calcification should be targeted therapeutically for the reduction of coronary heart disease.

Principal Investigator: Olga V. Savinova, Ph.D.

 

Kidney Development/Regeneration and the Evolution of Kidney Structure and Function

Studies the basic mechanisms underlying kidney morphogenesis and regeneration. Work focuses on the role of cell migration in kidney development and repair using transgenic zebrafish. Evolution of post-embryonic nephrogenesis in vertebrates, from fish to mammals is also studied.

Principal Investigator: Aleksandr Vasilyev, M.D., Ph.D.

 

The Role of DNA Damage Response and DNA Repair in Tumorigenesis and Cancer Therapy

Focuses on the role of Breast Cancer Gene 1 (BRCA1) in DNA damage response and DNA repair. Also explores novel synthetic lethal strategies to target breast cancers and ovarian cancers bearing the BRCA1 mutations.

Primary investigator: Dong Zhang, Ph.D.

 

Heart Failure and Atrial Fibrillation

Studies the mechanisms for enhanced atrial fibrillation arrhythmogenesis in heart failure and develops potential treatment options to improve outcome. Also studies the mechanisms for the dual pathway atrioventricular node electrophysiology.

Primary investigator: Youhua Zhang, M.D., Ph.D.