Dong Zhang teaches medical biochemistry and specializes in cancer biology, cell biology, and molecular biology. His research focuses on DNA damage checkpoint, DNA repair, and centrosome biogenesis and its effects on the development and treatment of breast and ovarian cancer.
Zhang received his Ph.D. in biochemistry and molecular biology from Brandeis University and performed his postdoctoral training at Baylor College of Medicine and Harvard Medical School.
Recent Projects and Research
- Target Breast Cancer and Ovarian Using Synthetic Lethal Strategy
- Investigate Crosstalk Between DNA Damage Response and Centrosome Biogenesis
- Investigate Molecular Mechanism of DNA Damage Checkpoint and DNA Repair
Publications and Presentations
- Xiaolei Pan, William C. Drosopoulos, Louisa Sethi, Carl L. Schildkraut, and Dong Zhang FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres. Proc Natl Acad Sci U S A., 2017 Jul 18; 114 (29):E5940-E5949. doi: 10.1073/pnas.1708065114. Epub 2017 Jul 3. (Journal Impact Factor-2014: 9.809);
- Zou J, Zhang DL, Qin G, Chen XM, Wang H, and Zhang D. BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Cell Cycle 2014 Dec 1;1(23): 3685-97; PMID: 25483079.
- Tian T, Sharma S, Zou JQ, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, and Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A., 2013 110:33, 13558-13563; PMID: 23901102.
- Zhang D, Zaugg K, Mak TW, Elledge SJ. A role for the deubiquitinating enzyme usp28 in control of the DNA-damage response. Cell. 2006; 126:529-542; PMID: 16901786.
Honors and Awards
- Breast Cancer Fellowship, Baylor College of Medicine
- Gillette Fellowship, Brandeis University
Courses Taught at New York Tech
- Gastrointestinal System
- Respiratory System
- Cardiovascular System
- Foundations of Osteopathic Medicine