Student Presenter(s): Sally Lee
Faculty Mentor: Azhar Ilyas
Department: Electrical and Computer Engineering
School/College: College of Arts and Sciences, Long Island

Bone-related disorders such as osteoporosis and giant cell tumors of the bone affect nearly 200 million people. Both disorders are unpredictable and difficult to diagnose, leading to late treatment plans. Treatment options available also come with risks and complications, suggesting the need for an improvement that promotes and supports the natural healing process of bone tissue. Zoledronic acid appears to be a good candidate to mediate the symptoms of these disorders due to their effects on calcium levels by causing apoptotic death of osteoclasts. Ongoing research has also revealed promising results for the use of metal alloys such as magnesium and strontium due to the effects of these cations within the body. Mg2+ helps to promote the release of calcitonin and with the addition of zoledronic acid, osteoclastogenesis is inhibited through the Nk-B pathway. This review highlights and summarizes the use of zoledronic acid alone as well as its usage with magnesium-strontium based alloys to regulate osteoclastogenesis.