Satoru Kobayashi received his Ph.D. from the United Graduate School of Agricultural Sciences, Iwate University (UGAS), Japan and has expertise in Biochemistry, Molecular Biology, Cell Biology and Physiology. He has dedicated over ten years of his academic career to the basic research of cardiovascular diseases. The objective of his research is to develop new therapeutic strategies to prevent and/or cure any heart disease. His current research focuses on the lysosome function to elucidate the mechanisms that mediate diabetic cardiomyopathy and heart failure, a leading cause of death for diabetic patients.
- Lysosomal Dysfunction in Diabetic Cardiomyopathy
- Kobayashi S. Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy. Biol Pharm Bull. 2015;38(8):1098-103. doi: 10.1248/bpb.b15-00096.. PMID 2623572 (Review article).
- Kobayashi S, Liang Q. Autophagy and mitophagy in diabetic cardiomyopathy Biochim Biophys Acta. Epub 2014 May 29. doi: 10.1016/j.bbadis.2014.05.020. PMID 24882754 (Review article).
- Kobayashi S, Xu X, Chen K, Timm D, Volden P, Gulick J, Yue Z, Robbins J, Epstein PN, and Liang Q. Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes. J Biol Chem. 2013, Epub 2013 May 8. doi: 10.1074/jbc.M113.474650.
- Chen K, Xu X, Kobayashi S, Viollet B, and Liang Q. AMP Activated Protein Kinase Is Indispensable for Myocardial Adaptation to Caloric Restriction in Mice. PLoS ONE 2013 8(3): e59682. Epub 2013 Mar 19. doi:10.1371/journal.pone.0059682.
- Kobayashi S, Xu X, Chen K, and Liang Q. Suppression of Autophagy Is Protective in High Glucose-Induced Cardiomyocyte Injury. Autophagy 2012 Apr; 8(4) 1-16. doi: 10.4161/auto.18980.
Honors and Awards
- American Heart Association Scientist Development Grant (15SDG25080077). Lysosomal Dysfunction in the Diabetic Heart. 7/1/2015–6/30/2019, $308,000.
- Juvenile Diabetes Research Foundation International Advanced Postdoctoral Fellowship (10-2008-457). Dissecting the Role of Autophagy in Type I Diabetes-Induced Cardiomyopathy. 9/1/2008–8/31/2011, $270,000.
- The American Heart Association Postdoctoral Fellowship (0625755Z). Transcription Factor GATA4 Protects from Doxorubicin-induced Cardiotoxicity through Anti-apoptotic Gene Bcl2. 7/1/2006–6/30/2008.
- Outstanding Research Award (3rd place): "Diabetic Ketoacidosis Compromises Cardiac Mitochondrial Quality Control in Humans." Kobayashi S, Gilliland M.G.F, Hoffman W.H, O'Connor A, Jung MK, and Liang Q. The Second Annual ACRE/APS Symposium: Hot Topics in Current Basic and Translational Research of CV disease, July 12, 2015, New Orleans, LA.
- New Investigator Travel Award "Regulation of Akt/PKB activity by P21-activated Kinase in Cardiomyocytes", 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, July 2007, Keystone, CO.
Courses Taught at New York Tech
- Academic Scholars program and research