Subhabrata Chaudhury

Subhabrata Chaudhury

Title
Assistant Professor
Department
Biological and Chemical Sciences
Campus
Long Island
Area(s) of Expertise
Organic and Medical Chemistry
Education Credentials
Ph.D.
Joined New York Tech
2023

Subhabrata Chaudhury, Ph.D., is an organic chemist. His research is focused on developing small molecule-based therapeutics for several diseases including cancer, diabetes, and Alzheimer's disease. He has developed several small molecule inhibitors that are selective for Hsp90-beta (Hsp90-β) isoform. Hsp90-β is a biological target in cancer chemotherapeutics. Chaudhury has also worked on the scalable synthesis of various small molecules that are potent and selective estrogen receptor-β (ERβ) agonists as potential drug candidates for depression, anxiety, and dementia associated with menopausal women. Some of these molecules are in pre-clinical trials. His industrial experience comes from working as a team leader (medicinal chemistry) in oncology and virology.

Chaudhury's training in organic synthesis was at the Indian Institute of Technology-Kharagpur (M.Sc.), and then at Marquette University (Ph.D.) as a student. He worked as a researcher in several institutes including the University of Kansas, the Medical College of Wisconsin, the University of Glasgow, and the University of Notre Dame. He was also a visiting assistant professor at Marquette University. Chaudhury serves as a peer reviewer for several chemistry and medicinal chemistry journals.

Recent Projects and Research

  • Design, synthesis, and bio-evaluation of potent and selective small molecule modulators of pyruvate carboxylase (PC) enzyme as potential drug candidates for cancer and diabetes.
  • Development of L-type amino acid transporter-1 (LAT-1) selective inhibitors as potential cancer drugs.
  • Development of new cycloaddition methodologies using trimethylenemethane-transition metal complexes.

Selected Publications

  • "Discovery of two novel (4-hydroxyphenyl) substituted polycyclic carbocycles as potent and selective estrogen receptor beta agonists" Wetzel, E. A; Marks, Gleason, A. A.; K. J., Brown-Ford, S.; Reid, T.; Chaudhury, S,; Lindeman, S.; Sem, D. S.; Donaldson, W. A. Bioorganic & Medicinal Chemistry Letters 2022, 73, 128906.
  • "Structure-based design, synthesis and biological evaluation of Hsp90β-selective inhibitors" Chaudhury, S.; Meka, P. N,; Banerjee. M.; Blagg, B. S. J. Chemistry – A European J. 2021, 27, 14747–14764
  • "The Role and Therapeutic Potential of Hsp90, Hsp70, and Smaller Heat Shock Proteins in Peripheral and Central Neuropathies" Chaudhury, S.; Keegan B. M; Blagg, B. S. J. Medicinal Research Reviews 2021, 41, 202–222
  • "Reactivity of (3-Methylpentadienyl)iron(1+) Cation: Late-stage Introduction of a (3-Methyl-2Z,4-pentadien-1-yl) Side Chain" Chaudhury, S.; Li, S.; Donaldson, W. A. Mediterranean Journal of Chemistry 2016, 5, 540–547
  • "Synthesis of the A-D ring system of the Gambieric Acids" Clark, S. J.; Romiti, F.; Sieng, B.; Paterson, L. C.; Stewart, A.; Chaudhury, S.; Farrugia, L. J. Organic Letters 2015, 17, 4694–4697.
  • "Generation of molecular complexity from cyclooctatetraene using dienyliron and olefin metathesis methodology" El-Mansy, M. F.; Sar, A.; Chaudhury, S.; Wallock, N. J.; Donaldson, W. A. Organic & Biomolecular Chemistry 2012, 10, 4844–4846.
  • "Recent Applications of Acyclic (Diene)iron Complexes and (Dienyl)iron Cations in Organic Synthesis" Donaldson, W. A.; Chaudhury, S. European Journal of Organic Chemistry 2009, 3831–3843.
  • "Preparation, Characterization and Reactivity of (3-Methylpentadienyl)iron(+1) Cations" Chaudhury, S.; Li, S.; Bennett, D. W.; Siddiquee, T.; Haworth, D. T.; Donaldson, W. A. Organometallics 2007, 26, 5295–5303.
  • "Generation of molecular complexity from cyclooctatetraene: synthesis of a protected 2-(3/-carboxy-2/-benzoylcyclopentyl)glycine" Chaudhury, S.; Lindeman, S.; Donaldson, W. A. Tetrahedron Letters 2007, 48, 7849–852.
  • "Hsp90 as a target for drug development" Chaudhury, S.; Welch, T. R.; Blagg, B. S. J. ChemMedChem. 2006, 1, 1331–1340.
  • "Synthetic studies directed towards the proposed structure for heteroscyphic acid A" Chaudhury, S.; Li. S.; Donaldson, W. A. Journal of Chemical Society, Chemical Communications 2006, 19, 2069–2070.
  • "Crystal and molecular structure of bis(8-phenylmenthyl) 2-(2methyl-5-oxo-3-cyclohexen-1-yl)propionate, C42H54O5.CH3CN" Bennett, D. W.; Siddiquee, T.; Haworth, D. T.; Chaudhury, S.; Donaldson, W. A. Journal of Chemical Crystallography 2006, 36, 777–780.
  • "Nucleophilic addition to (3-methylpentadienyl)iron(+1) cations: counterion control of regioselectivity; application to the enantioselective synthesis of 4,5-disubstituted cyclohexenones" Chaudhury, S.; Donaldson, W. A. Journal of American Chemical Society 2006, 128, 5984–5985.
  • "Synthesis and reactivity of tricarbonyl(1-methoxycarbonyl-5-phenylpentadienyl)iron(1+)cation" Chaudhury, S.; Donaldson, W. A.; Bennett, D. W.; Haworth, D. T. Siddiquee, T. A; Kloss, J. M. Donaldson, W. A. Journal of Organometallic Chemistry 2004, 689, 1437–1443.

Courses Taught at New York Tech

  • CHEM 210

Contact Info