Jacqueline Keighron earned her Ph.D. in chemistry at Penn State University in the laboratory of Dr. Christine Keating, where she studied the interactions of enzymes with nanostructured materials. Her dissertation focused on the creation and characterization of enzyme-nanoparticle bioconjugates as model systems for the multi-enzyme complexes that exist in biological cells.
Following graduate school, Keighron conducted her postdoctoral research in the laboratories of Drs. Andrew Ewing and Ann-Sofie Cans at Chalmers University of Technology in Gothenburg, Sweden. In the Ewing lab, Kreighron studied dopamine dynamics in vivo and in vitro, employing a variety of analytical techniques. In the Cans lab, she helped develop ultra-fast electrochemical methods for detecting non-electroactive neurotransmitters, including acetylcholine and glutamate.
Upon returning to the U.S., Keighron was awarded a fellowship at the National Institute on Drug Abuse in Baltimore, Md., as part of the Medications Development Program under the leadership of Drs. Amy Newman and Gianluigi Tanda. There, she studied the effects of psychostimulants of abuse on dopamine dynamics and the neurochemistry of potential treatments for psychostimulant abuse.
Recent Projects/Research
- Keighron's current research interests include using ultrafast and multianalyte biosensors to study the dynamics of glutamate and dopamine in vivo, as well as the neurochemical effects of drug molecules that have both therapeutic and abusive properties.
Publications
- Newman, A. H.; Cao, J.; Keighron, J. D.; Jordan, C. J.; Bi, G.-H.; Liang, Y.; Abramyan, A.; Avelar, A. J.; Tschumi, C. W.; Beckstead, M. J.; Shi, L.; Tanda, G.; Xi, Z.-X. (2019). Translating the atypical dopamine uptake inhibitor hypothesis toward potential therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology, 44(8):1435.
- Keighron J.D.; Quarterman, J.; DeMarco, E.; Coggiano, M.A.; Slack, R.; Cao, J.; Newman, A. H.; Tanda, G. (2019). Effects of R-Modafinil and Modafinil-Analogs on dopamine dynamics assessed by voltammetry and microdialysis in the mouse nucleus accumbens shell. 10:2012–2021.
- Wang, Y.; Mishra, D.; Bergman, J.; Keighron, J.D.; Skibicka, K.; Cans, A.-S. (2019). Glutamate biosensor recordings in brain slices reveal single exocytosis transients. ACS Chemical Neuroscience, 10:1744–1752.
- Keighron, J.D.; Giancola, J.B.; Shaffer, R.; DeMarco, E.; Coggiano, M.A.; Slack, R.D.; Newman, A. H.; Tanda, G. (2018). Distinct effects of (R)-Modafinil and its (R)- and (S)-fluoro-analogs on mesolimbic extracellular dopamine assessed by voltammetry and microdialysis. doi:10.1111/ejn.14256
- Keighron, J.D.; Wigström, J.; Kurczy, M.E.; Bergman, J.; Wang, Y.; Cans, A.-S. (2015). Amperometric detection of single vesicle acetylcholine release events from an artificial cell. ACS Chemical Neuroscience, 6:181–186.
Courses Taught at New York Tech
- Bio 340: Biochemistry