News: College of Osteopathic Medicine
Nov 11 2011
Dr. Victoria Rudenko, former fellow in the laboratory of Dr. L Friedman, Associate Professor of Neuroscience & Histology in 2009 and graduate of NYCOM in 2011, is the first author on a novel finding showing that cannabinoids have biphasic effects in development.
The study illustrated that a low dose injection of a cannabimimetic abolishes seizures in the juvenile brain whereas high doses induce stupor and were proconvulsant. Results imply that administration of an optimal dose of a cannabamimetic or inducing optimal endogenous increases of postnatal cannabinoid synthesis may provide a therapeutic strategy for controlling seizures during certain stages in development without psychoactive or deleterious side-effects.
Now available online at: http://dx.doi.org/10.1016/j.pbb.2011.10.005
Publication: Rudenko V., Rafiuddin A., Leheste JR, and Friedman LK. Inverse relationship of cannabimimetic (R+)WIN55, 212 on behavior and seizure threshold during the juvenile period. Pharmacology, Biochemistry and Behavior.