One medical discovery often leads to others,
and Assistant Professor Steven Youmans, Ph.D., is banking
on that being the case for Lipitor. Right now, he’s
conducting research to see whether the cholesterol-lowering
drug may also hold the key to curing kidney disease. And Pfizer
Inc., Lipitor’s manufacturer, is so interested in the
possibility that it has provided a $100,000 grant to Youmans
to conduct initial research.
The professor says there is some evidence that the drug might
prevent a damaging protein from entering renal (kidney) cells.
What’s more, tests have shown that this protein, which
is normally present at low levels in the blood, is elevated
in people who suffer from renal disease.
Lipitor works similarly to prevent heart disease, blocking
an enzyme in the liver that produces cholesterol. By decreasing
cholesterol, the liver is forced to use more, thus lowering
the levels of potentially life-threatening steroid alcohol
in the blood.
The one-year research project, which is being conducted at
Winthrop University Hospital in Mineola, N.Y., as well as
NYIT, will look at Lipitor’s impact on cultured kidney
cells and on mice kidneys.
According to the National Kidney Foundation, more than 20
million Americans—one in nine—have chronic kidney
disease.
“This research could have huge implications,”
says Youmans. “It may prove that Lipitor has the potential
to prevent, treat, slow down, or maybe even reverse kidney
disease.”
Youmans is working on the research with fellow NYIT Assistant
Professor Joerg R. Leheste, Ph.D., research associate Miriam
Cohen, and John Maesaka, M.D., of Winthrop’s renal division.
The researcher believes that collaborations among scientists
and clinicians can help unlock many medical mysteries.”
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With a $100,000 grant from Pfizer, Assistant
Professor Steven Youmans, Ph.D., and fellow NYIT colleagues
study the effects of Lipitor on kidney disease.
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