Life Sciences Admissions
Contact Us

Department of Life Sciences

NYIT
Theobald Science Center
Old Westbury, NY 11568-8000
516.686.3883
.(JavaScript must be enabled to view this email address)

The Life Sciences Department offers degrees at our campuses in New York City and Long Island, NY.


Michael Hadjiargyrou, Ph.D.

Michael Hadjiargyrou

Professor and Chair
Department of Life Sciences

Old Westbury Campus
Theobald Science Center, Room 420

Phone: 516.686.7738
Fax: 516.686.3853
Email: mhadji@nyit.edu

Education

B.A., Biology/Philosophy, City University of New York, New York City, 1986
M.A., Biology, City University of New York, New York City, 1988
Ph.D., Molecular Biology, City University of New York, New York City, 1992
Post-Doctoral, Cell/Molecular Biology, California Institute of Technology, Pasadena, CA, 1992-96

Research and Professional Experience

  • 1987-88, Laboratory Instructor of Biology, Department of Biological Sciences, Hunter College, CUNY
  • 1988-91, Recitation Instructor of Biology, Department of Biological Sciences, Hunter College, CUNY
  • 1988-92, Graduate student, Department of Biological Sciences, Hunter College, CUNY
  • 1992-95, Post-doctoral Fellow, Division of Biology, California Institute of Technology
  • 1995-96, Senior Post-doctoral Fellow, Division of Biology, California Institute of Technology
  • 1996-98, Research Assistant Professor, Department of Orthopaedics and Program in Biomedical Engineering, Stony Brook University
  • 1998-03, Assistant Professor, Department of Biomedical Engineering, Stony Brook University
  • 2003-12, Associate Professor, Department of Biomedical Engineering, Stony Brook University
  • 2005-07, Graduate Program Director, Department of Biomedical Engineering, Stony Brook University
  • 2007-10, Associate Vice President for Research, Stony Brook University
  • 2007-10, Member, Advocacy Committee, American Society for Bone and Mineral Research, Washington, DC
  • 2007-present, Associate Editor, Journal of Biomedical Nanotechnology
  • 2008-14, Editorial Advisory Board Member, The Open Nanomedicine Journal
  • 2008-present, Editorial Advisory Board Member, The Open Bone Journal
  • 2011-present, Editorial Advisory Board Member, Journal of Regenerative Medicine and Tissue Engineering
  • 2012-present, Professor and Chair, Department of Life Sciences, New York Institute of Technology
  • 2013-present, Associate Research Professor, Department of Orthopaedics, Stony Brook University
  • 2014-present, Editorial Advisory Board Member, Open Nanotechnology and Nanomedicine Journal

Honors

  • 1984, New York University Medical Center, DeWitt Wallace Reader's Digest Fellow
  • 1986, City University of New York, The Presidential Prize for Academic Excellence in Philosophy
  • 1988-91, City University of New York, Graduate Teaching Fellowship
  • 1989, City University of New York, The Beatrice Goldstein Konheim Graduate Scholarship in the Life Sciences
  • 1990, Hellenic University Club of New York,The Frederick E.G. Valergakis Award
  • 1992-93, California Institute of Technology, American Heart Association Research Fellowship
  • 1993-96, California Institute of Technology, NIH NRSA
  • 2001, Outstanding Teacher of the Year, Department of Biomedical Engineering, Stony Brook University
  • 2002, Who's Who in Engineering Education
  • 2002, Who's Who in Medicine and Healthcare
  • 2003, Who's Who in America
  • 2003, Who's Who in Science and Engineering
  • 2003, Outstanding Teacher of the Year, Department of Biomedical Engineering, Stony Brook University
  • 2005, First Patent Honoree, Research Foundation of New York
  • 2007, Outstanding Service Award, Department of Biomedical Engineering, Stony Brook University
  • 2008, President's Award for Team Achievement (Science And Research Awareness Series [SARAS])
  • 2008, Most Cited Paper Award for 2004, Journal of Controlled Release
  • 2011, The Academic Who's Who
  • 2012, Medicine Who's Who
  • 2013, Honorary Member, Phi Eta SIgma National Honor Society, NYIT Chapter
  • 2014, Mentor of the Year, Student Government Association, NYIT
  • 2015, Who's Who in America

Teaching

  • BIOL 110 General Biology I
  • BIOL 425 Biomedical Research I
  • BIOL 455 Biomedical Research II
  • BIOL 465 Biomedical Research III
  • BIOL 440 Genetic Engineering

Research Focus

The overall goal of my laboratory is to implement innovative approaches for engineering new musculoskeletal tissue utilizing knowledge derived from molecular and cellular biology and biomaterials. More specifically, we are actively involved in understanding the molecular mechanisms that underlie musculoskeletal development and regeneration. Previously, we have used fracture repair as an example to study tissue regeneration. The repair of a fractured bone is a complex biological event that essentially recapitulates embryonic development and requires the orchestration of a number of different cell types undergoing proliferation, migration, adhesion and differentiation, all under the direct control of a host of different genes.

Understanding the temporal and spatial expression of these genes during the progression of a healing callus will ultimately enable us to comprehend the essential processes of inflammation, chondrogenesis, ossification, and remodeling. The latest methods in molecular and cellular biology are applied in the pursuit of gene discovery, gene structure and function analysis, expression studies and functional perturbations. By identifying and studying genes that play essential roles during tissue repair, we hypothesize that this knowledge will facilitate a greater understanding in our ability to elucidate the process of musculoskeletal development and regeneration and identify ideal gene candidates for possible therapeutic intervention via the use of biomaterials.

Selected Publications

  • Hadjiargyrou, M., Lombardo, F., Zhao, S., Ahrens, W., Joo, J., Ahn, H., Jurman, M., White, D.W. and Rubin, C.T. (2002) Transcriptional profiling of bone regeneration: Insight into the Molecular Complexity of Wound Repair. J. Biol. Chem. 277:30177-30182.
  • Luu, Y.K., Kim, K., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2003) Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J. Control Release 89:341-353.
  • Lombardo, F., Komatsu, D., and Hadjiargyrou, M. (2004) Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during bone development and regeneration. The FASEB Journal 18:52-61.
  • Liang, D., Luu, Y.K., Kim, K., Hsiao, B.S., Hadjiargyrou, M. and Chu, B. (2005) In Vitro Non-viral Gene Delivery with Nano-fibrous Scaffolds. Nucl. Acids Res. 33:e170.
  • Zhong, N., Gersch, P.R., and Hadjiargyrou, M. (2006) Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone 39:5-16.
  • Komatsu, D., Bosch-Marce, M., Semenza, G.L. and Hadjiargyrou, M. (2007) Enhanced Bone Regeneration Associated with Decreased Apoptosis in Mice with Partial HIF-1a Deficiency. J. Bone Miner. Res. 22:366-374.
  • Chiu, J., Liu, C., Hsiao, B.S., Chu, B. and Hadjiargyrou, M. (2007) Functionalization of Poly(L-lactide) (PLLA) Nanofibrous Scaffolds with Bioactive Collagen Molecules. J. Biomed. Mater. Res. A 83:1117-27
  • Gersch, R.P. and Hadjiargyrou, M. (2009) Mustn1 is expressed during chondrogenesis and is necessary for chondrocyte proliferation and differentiation in vitro. Bone 45:330-338.
  • Mironava, T., Hadjiargyrou, M., Simon, M., Jurukovskic, V. and Rafailovich, M.H. (2010) Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time. Nanotoxicology 4:120-137.
  • Liu, C., Gersch, RP, Hawke, T.J. and Hadjiargyrou, M. (2010) Silencing of Mustn1inhibits myogenic fusion and differentiation. Am. J. Physiol. Cell Physiol. 298:C1100-C1108.
  • Ke, F., Luu, YK., Hadjiargyrou, M. and Liang, D. (2010) Characterizing DNA Condensation and Conformational Changes in Organic Solvents. PLoS ONE 5.e13308.
  • Komatsu DE., Thanos PK., Mary MN., Janda HA., John CM., Robinson, L., Ananth, M., Swanson J.,Volkow ND. and Hadjiargyrou M. (2012) Chronic Exposure to Methylphenidate Impairs Appendicular Bone Quality in Young Rats. Bone 50: 1214-1222.
  • Gersch, RP., Kirmizitas, A., Sobkow, L., Sorentino, G., Thomsen, GH. and Hadjiargyrou M. (2012) Mustn1 is essential for craniofacial chondrogenesis during Xenopus development. Gene Expr. Patterns. 12:145-153.
  • Achille, C., Sundaresh, S., Chu, B. and Hadjiargyrou, M. (2012) Cdk2 Silencing via a DNA/PCL Electrospun Scaffold Suppresses Proliferation and Increases Death of Breast Cancer Cells. PLoS ONE 7: e52356.
  • Krause, MP., Moradi, J., Coleman, S., D’Souza, D., Liu, C., Kronenberg, M.S., Rowe, D.W., Hawk,T.J, Hadjiargyrou, M. (2013) A novel GFP reporter mouse reveals Mustn1 expression in adult regenerating skeletal muscle, activated satellite cells and differentiating myoblasts.  Acta Physiologica 208:180-190.
  • Mironava, T., Hadjiargyrou, M., Simon, M., and Rafailovich, M.H. (2014) Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells. Nanotoxicology 8:189-201.

Patents

  • Cell delivery system comprising a fibrous matrix and cells. US Patent #6,790,455. Issued on September 14, 2004.
  • Mustang, a gene and nuclear protein. US Patent #7,238,799. Issued on July 3, 2007.
  • Cell delivery system comprising a fibrous matrix and cells. US Patent (Continuation) #7,323,190. Issued on January 29, 2008.
  • Method of cell storage in a delivery system comprising a fibrous matrix. US Patent #8,021,869. Issued on September 20, 2011.

Memberships in Professional Societies

  • 1997-present Member, American Society for Bone and Mineral Research
  • 1997-present Member, Federation of American Societies for Experimental Biology