Niharika Nath, Ph.D.

Faculty Profile - Department of Life Sciences

Niharika Nath, Ph.D. 
Assistant Professor
E-mail: nnath@nyit.edu

Education

Ph.D. Indian Institute of Technology-Delhi, New Delhi, India, 1996.
M.S. in Biotechnology, Jadavpur University, Calcutta, India, 1989.
B. Pharmacy, College of Pharmacy, Delhi University, New Delhi, India, 1987.

Previous Research Appointments

2003–Present: Assistant Professor, Dept. of Life Sciences, NYIT
2002–2004: Associate Research Scientist, Physiology & Pharmacology, CUNY Medical School, N.Y.
2002-2004: Visiting Scientist, Nutritional Carcinogenesis, Institute for Cancer Prevention, N.Y.
1997–2002: Post-Doctoral Research Scientist, Columbia University, N.Y.

Previous Teaching Appointments

2004-2005: Adjunct Professor, Life Sciences, NYIT
2000-2002: Adjunct Professor, Biotechnology MS Program, Manhattan College, N.Y.

Society Memberships

1997-1999: New York Academy of Sciences
1998-Present: American Association for Cancer Research

Publications

• Nath, N.  and Deb, J.K. : Partial characterization of small multiple plasmids of Corynebacterium renale: PLASMID 1995 34, 3, 229-233.

• Nath, N. and Deb, J.K.: Curing of multiple plasmids of Corynebacterium renale : cephaloridine resistance and lactose metabolism are not plasmid coded. : BIOTECHNOLOGY LETTERS 1997, 19, 2, 163-166.

• Wang, S.*, Nath, N.*, Minden, A., Chellappan, S.P.: Regulation of Rb and E2F by signal transduction cascades: Divergent effects of JNK1 and p.38 kinases. EMBO JOURNAL 1999, 18 (6) 1559-1570. (*Co-first author)

• Nath, N., Bian, H., Reed, E.F., Chellappan, S.P.: HLA class I mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J. IMMUNOLOGY 1999, 162, 5351-5358.

• Deb, J.K. and Nath, N.:  Plasmids of corynebacteria. (minireview)  FEMS  MICROBIOLOGY LETTERS  1999, 175, 1, 11-20.

• Wang, S., Nath, N., Adlam M., Chellappan, S.P.: Prohibitin, a potential tumor suppressor, interacts with Rb and regulates E2F function. ONCOGENE. 1999, 18 (23), 3501-3510.

• Wang, S., Nath, N., Fusaro, G., Chellappan, S.P.: Rb and Prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. MOL. CELL. BIOL. 1999, 19(11):7447-60.

• Gewirtz DA, Di YM, Randolph JK, Jain PT, Valerie K, Bullock S, Nath N, Chellappan SP. RB dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol. ARCH BIOCHEM BIOPHYS. 2001, 388(2):243-52.

• Dan, C., Nath,  N., and Minden, A: PAK5, a novel effector for Rac and Cdc42Hs, is highly expressed in the brain and promotes neurite outgrowth in NIE-115 cells. MOL. CELL. BIOL. 2002, 22(2):567-77.

• Nath, N., Wang S., Betts, V., Knudsen, E., and Chellappan, S.P.  Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of  p38 and cyclin-dependent kinases. ONCOGENE 2003, 22, 5986-5994.

• Nath, N., Kashfi, K and Rigas, B. NO-donating aspirin inhibits beta-catenin  /TCF signaling in SW480 colon cancer cells more potently than aspirin by disrupting the nuclear beta-Catenin  – TCF association. PROC. NATL. ACAD. SCI. (U S A). 2003; 100(22):12584-12589.

• Williams, J.*, Nath, N.*, Chen, J., Hundley, T., Kashfi, K and  Rigas, B. Growth Inhibition of Human Colon Cancer Cells by Nitric Oxide (NO)-Donating Aspirin Is Associated with Cyclooxygenase-2 Induction and beta -Catenin/T-Cell Factor Signaling, Nuclear FactorK-B and NO Synthase 2 Inhibition: Implications for Chemoprevention. CANCER RESEARCH 2003, 63(22):7613-7618. (*Co-first author)

• Nath, N., Labaze, G. , Rigas, B. and Kashfi, K. NO-donating aspirin inhibits growth of leukemic Jurkat cells and modulates beta-catenin expression. BIOCHEM. BIOPHYS. RES. COMM. 2005, 326:93-99.

Recent Abstracts

• Nath, N., Vassell, R. , Rigas, B.and  Kashfi, K. NO-ASA strongly inhibits Wnt/ beta -catenin signaling in Breast Cancer MCF-7 cells.The Third Annual Meeting of AACR: Frontiers in Cancer Prevention, Oct 2004, Seattle.

• Nath, N., Labaze, G. , Rigas, B. and  Kashfi, K. NO-donating Aspirin (NO-ASA) modulates beta- catenin expression in cultured Human Leukemia cells. The Third Annual Meeting of AACR: Frontiers in Cancer Prevention, Oct 2004, Seattle.

• Nath, N., Kashfi, K and Rigas, B. "NO donating aspirin inhibits the Wnt signaling pathway more potently than aspirin". The 94th Annual Meeting of American Association for Cancer Research (AACR), July 2003, Washington D.C.

• Liu D.X., Nath, N., Chellappan S.P., Greene, L.A. Regulation of neuronal survival and apoptosis by the E2F-p130/ HDAC1/ Suv39H1 repressor complex. Cell Death Meeting, Cold Spring Harbor, NY, Sept 17-21, 2003.