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Department of Life Sciences

NYIT
Theobald Science Center
Old Westbury, NY 11568-8000
516.686.3883
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The Life Sciences Department offers degrees at our campuses in New York City and Long Island, NY.


Niharika Nath, Ph.D.

Niharika Nath

Associate Professor
Department of Life Sciences

Edward Guiliano Global Center, room 901A  
1855 Broadway, New York, NY 10023 

Phone: 212.261.1623 
Fax: 212.261.1680 
Email: nnath@nyit.edu

Education

Post Doctoral Research- Columbia University; City University of New York, 1997-2004 (research area Cancer Biology)
Ph.D. Indian Institute of Technology-Delhi, New Delhi, India, 1996.
M.S. in Biotechnology, Jadavpur University, Calcutta, India, 1989.
B. Pharmacy, College of Pharmacy, Delhi University, New Delhi, India, 1987.

Specializations

Carcinogenesis, Cancer chemoprevention and drug development
Plasmid biology, Biotechnology

Research and Professional Experience

  • M.S. Thesis Research (Immunobiology), Indian Institute of Chemical Biology, India, 1989
  • Senior Research Assistant (Restriction Enzyme purification), Indian Institute of Technology-Delh, India, 1990
  • Research Fellow (Plasmid Biology), Indian Institute of Technology-Delh, India, 1991-1996
  • Post Doctoral Research Scientist, Oncology, Columbia University, 1997- 2002
  • Associate Research Scientist, Physiology and Pharmacology, CUNY Medical School, CUNY, 2002-2004
  • Reviewer of PSC-CUNY research grant applications, 2004
  • Adjunct Professor and Thesis Advisor, MS Biotechnology Program, Manhattan College, NY, 2002 -2003
  • Adjunct Professor, Life Sciences, NYIT, 2004-2005
  • Medical Writer, CommonHealth, 2005 -2006
  • Assistant Professor, Life Sciences, NYIT, 2005-2010
  • Associate Professor, Life Sciences, NYIT, 2010-present
  • Director, Center of Undergraduate Research and Creative Expression (COURCE), NYIT, 2008-2010
  • Collaborations- CUNY Physiol. & Pharmacol. Dept , 2006-present
  • Collaborations - Indian Institute of Technology-Delhi, India, Corynebacterial genome project 2004-2006
  • Collaborations- SABiosciences Corporation, Maryland, Gene silencing studies, 2008-2009
  • Collaborations- CUNY Biomed. Engg. Dept, 2012
  • Member of Core Curriculum Committee, and Course Creator Foundation of Science Core course, 2008-2009
  • Member, SOURCE committee, 2005- present
  • Member, Academic Senate NYIT, 2010-2012
  • Member, Department Personnel Committee, 2010- present
  • Reviewer for Journals European Journal of Pharmacology, British Journal of Cancer, Cancer Chemotherapy and Pharmacology, World Journal of Surgical Oncology

Honors (and Accomplishments)

  • Jawaharlal Nehru Master's in Biotechnology Program Fellowship, Jadavpur University, India, 1987-1989
  • Junior and Senior Research Fellowship, Indian Institute of Technology-Delhi , 1991 - 1995
  • Recipient PSC-CUNY research grant award #66238-00-35, 2004
  • Standard of Excellence Award (NYIT/NYCOM) and Outstanding Service Award (NYIT School of Health Professions & Life Sciences) for promotion of undergraduate research, 2008
  • Institutional Teaching and Learning Grant Award, 2009
  • Guest Lecturer, Biomedical Sciences, Long Island University, CW Post, NY, 2009
  • Judges Travel Award, American Society for Microbiologists- Annual Biomedical Research Conference for Minority Students, 2009
  • Invited Speaker, Department of Biology, Adelphi University, NY, 2010
  • College of Arts and Science Faculty Development Award, 2010
  • Mentoring Success- ABRCMS conference Undergraduate Travel Award to W. Abdel-Naby for presenting on molecular mechanisms of novel NSAIDs, 2010
  • Invited Speaker, International Conference on Emerging Areas of Chemistry, Tripura University, India, 2011
  • Mentoring Success- NYIT College of Arts & Sciences Dean's Travel Awards to T Thuy, K Munawar, A Haq for presenting on molecular mechanisms of hydrogen releasing compounds at BMES conference, 2011
  • Invited Speaker, Golden Key Society-NYIT chapter, 2011
  • Institutional Support for Research and Creativity Grant Awards, 2006, 2010, 2012

Teaching

  • Cell Biology - Lecture and Lab
  • Microbiology- Lecture and Lab
  • General Biology I - Lecture and Lab
  • General Biology II - Lecture and Lab
  • Biomedical Research I - Capstone undergraduate experience (Cancer Biology)
  • Biomedical Research II- Capstone undergraduate experience (Cancer Chemoprevention)
  • Foundations of Science- Pilot Course
  • Project SEED Summer Research (American Chem. Soc.)- novel compounds targeting beta-catenin
  • Thesis research (MS) - Molecular mechanisms of NSAID derivatives

Research Focus

My research investigates some of the signaling pathways involved in carcinogenesis and progression of cancers and modulation of these pathways by novel agents such as nonsteroidal anti-inflammatory drugs modified to release gasotransmitters, such as nitric oxide and hydrogen sulfide. Main focus of study are modulation of the Wnt/ beta-catenin signaling pathway which is a dysregulated early event in colorectal cancer, as well as the interplay of transcription factor NF-kappaB, the enzyme cyclooxygenase-2, nitric oxide synthase enzyme and apoptotic pathway proteins on cell growth, apoptosis and inflammation. The questions posed at the molecular level are possibility of signaling through protein modification such as nitrosylation. Other interests include investigating these and other novel agents for anti-cancer effects by 3-dimensional arrays that simulate the tumor environment.

Selected Publications

  • Nath N, Chattopadhyay M, Pospishil L, Cieciura LZ, Goswami S, Kodela R, Saavedra JE, Keefer LK, Kashfi K. JS-K, a nitric oxide-releasing prodrug, modulates beta-catenin/TCF signaling in leukemia Jurkat cells: evidence of an S-nitrosylated mechanism. Biochem Pharmacol. 2010;80:1641-9.
  • Nath N, Kashfi K, Chen J, Rigas B. NO-donating aspirin inhibits beta-catenin/TCF signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association. Proc Natl Acad Sci USA, 2003; 100:12584-9.
  • Nath N, Chattopadhyay M, Kodela R, Tian S, Vlismas P, Boring D, Crowell JA, Kashfi K. Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells. Biochem Pharmacol. 2010;79:1759-71.
  • Williams JL, Nath N, Chen J, Hundley TR, Gao JJ, Kashfi K, Rigas B. Growth inhibition of human colon cancer cells by NO-donating aspirin is associated with COX-2 induction and ?-catenin/TCF signaling, NF-kB and NOS2 inhibition: Implications for chemoprevention. Cancer Res, 2003; 63:7613-7618
  • Nath, N *, Vassel R, Chattopadhyay M, Kogan, M and Kashfi, K. Nitro-aspirin inhibits MCF-7 breast cancer cell growth: Effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. Biochem Pharmacol. 2009, 78:1298-1304
  • Srivastava, P., Nath, N, Deb, J.K. Characterization of broad host range cryptic plasmid pCR1 from Corynebacterium renale. Plasmid 2006, 56: 24-34

Memberships in Professional Societies

  • American Association for Cancer Research
  • New York Academy of Sciences
  • Honorary Member, Golden Key Society-NYIT chapter
  • Society of Biological Chemists, India

Community Leadership and Service

  • Organizer of 'Science Workshop Day' at Transfiguration Academy School, New Jersey, 2012 Abstract Reviewer for Amer. Soc. for Microbiol-ABRCMS undergraduate conference, 2011, 2012
  • Faculty Advisor of American Medical Students Association Chapter at NYIT
  • Judge at the -ABRCMS conference, 2009, 2010
  • Faculty Mentor, American Chemical Society Project SEED
  • Faculty Founder, 'Manhattan Life Science-NYIT Alumni Mentor Group'