Claude E.  Gagna, Ph.D., CChem MRSC, FAIC, ChE
Claude Gagna

Associate Professor
Department of Life Sciences

Old Westbury Campus
Theobald Hall, Room 430

Phone: 516.686.3877


Ph.D. - Human Anatomy (Minor: Biochemistry): New York University- Basic Medical Sciences, Dept. of Anatomy, and Dept. of Biochemistry, New York, NY
M.S. - Human Anatomy: Fairleigh Dickinson University - College of Dental Medicine, Dept. of Anatomy, Teaneck, NJ
B.S. - Natural Sciences (Minor: Biology): Saint Peter's College, Dept. of Biology, Jersey City, NJ

Academic And Professional Honors, Awards & Nominations

  • Gold Medal - Department of the Army (USA) "For Supporting the Veterans at NYIT" 2011
  • Nominee of "The World Technology Summit & Awards": Biotechnology (Individual Category) The World Technology Network, New York, NY 2011
  • Winner of the "15th Annual Spirit Award" for Outstanding Support, Dedication and Commitment to the Science Research Program. White Plains High School, New York 2011
  • Winner of the "Fourth NANO 50 Awards - Technology Category" (NASA) 2008
  • Nanotechnology Finalist - "Researcher of the Year" (Best of Small Technology Awards) 2007
  • New Jersey Inventor of the Year, New Jersey Inventors Hall of Fame - Research & Development Council of New Jersey 2006
  • Dean's "Award for Outstanding Research", NYIT 2004 and 2005
  • Standard of Excellence Award, New York College of Osteopathic Medicine, NYIT 2005
  • Faculty Scholars Reception Award, NYIT 2003, 2006 to 2012

Professional Designations Bestowed By Elected Membership

  • ChE (i.e., Chartered Chemical Engineer: Class - Member):
    American Institute of Chemical Engineers, New York, NY 1994 to present
  • CChem MRSC (i.e., Chartered Chemist. Member Royal Society of Chemistry):
    The Royal Society of Chemistry, Cambridge, UK 1994 to present
  • FAIC (i.e., Fellow American Institute of Chemists): The American Institute of Chemists, Inc., Bethesda, MD 1990 to present


  • Method for immobilizing multistranded nucleic acid molecules by modifying More than one strand thereof, and binding each strand to a solid support: Patent (United States) 6,936,461, Appl. No. 209849. August 30, 2005. Inventors: Gagna, Claude. Assignee: NYIT.
  • Method for immobilizing multistranded nucleic acid molecules by modifying more than one strand thereof, and binding each strand to a solid support: Patent (Japanese) No. 4201337. Appl. No. 200 - 517298, October 2, 2008. Inventors: Gagna, Claude. Assignee: NYIT.


  1. UMDNJ - Medical School, Department of Dermatology (Medicine): Seminar Series. Advanced Medical Research Topics in Dermatopathology (Medical Residency Program)...2003 to 2005
  2. NYIT - Department of Life Sciences:
    • Gross Human Anatomy (BIOL 210)
    • Gross Human Anatomy Laboratory (BIOL 210L)
    • Comparative Anatomy (BIOL 220)
    • Comparative Anatomy Laboratory (BIOL 220L)
    • Biomedical Research I (BIOL 425) (Section W02)
    • Histology (BIOL 245)
    • Histology Laboratory (BIOL 245L)
    • Biomedical Research II (BIOL 455) (Section W02)
    • Biomedical Research III (BIOL 465) (Section W02)
    • Biomedical Research IV (BIOL 490) (Section W02)

Clinical Diagnostic Laboratory Experience

Associate Director: Genomic Instability and Mutagenesis Laboratory. UMDNJ Medical School Newark, NJ. 2006 to present

Research Focus

As a scientist I perform molecular biological and histotechnological research on the structure and function of conventional (e.g., right-handed B-DNA), alternative (e.g., Z-DNA) and multi-stranded (e.g., triplex DNA) DNA and RNA molecules, in both normal and diseased tissue [e.g., eye (ocular lens) (cataracts), and skin (epidermis) (e.g., melanoma, Xeroderma Pigmentosum)]. As a nucleic acid nanotechnologist, I develop the next generation of DNA and RNA microarrays [i.e., Novel multistranded and alternative DNA, RNA and plasmid microarrays (transitional structural nucleic acid microarrays)]. This involves new ways of immobilizing intact, non-denatured unaltered nucleic acids to enhanced substrate surfaces.

In addition, I am also involved in developing techniques that can be used with the novel microarrays, viz., original genomic and proteomic techniques/methods (i.e., transitional structural chemogenomics, transitional structural chemoproteomics, transitional structural pharmacogenomics, and transitional structural pharmacoproteomics). Furthermore, I develop novel approaches to fixing tissues for superior histotechnological processing of preserved DNA, RNA and nucleic acid-protein complexes in tissues. These tissues can then be better characterized immunohistochemically and histochemically for the presence of nucleic acids.

Selected Publications

  • Patel LM, Lambert PJ, Gagna CE, et al. (2011) Cutaneous Signs of Systemic Disease. Clinics in Dermatology. 29: 511-522
  • Lambert WC, Gagna CE, Lambert MW. (2010) Trichothiodystrophy: Photosensitive, TTD- P, TTD, Tay Syndrome. Advances in Experimental Medicine and Biology. 685: 106 - 110
  • Gagna CE, Chan NJ , Farnsworth PN, Kuo H-R, Kanthala TR, Patel AH, Patel N, Law A, Patel PP, Richards SA, Yam T, Nici A, Lambert WC. (2009) Localization and quantification of intact, undamaged right-handed double-stranded B-DNA, and denatured single-stranded DNA in normal human epidermis and its effects on apoptosis and terminal differentiation (denucleation). Archives of Dermatological Research. 301:659-672.
  • Gagna CE, Lambert WC. (2009) Novel Multistranded, Alternative, Plasmid and Helical Transitional DNA and RNA Microarrays: Implications for Therapeutics. Pharmacogenomics. 10: 895-914.
  • Lambert WC, Gagna CE, Lambert MW (2008) Xeroderma Pigmentosum: Its Overlap with Trichothiodystrophy, Cockayne Syndrome and Other Progeroid Syndromes. Advances in Experimental Medicine and Biology. 637: 128-37.
  • Gagna CE, Kuo HR, Mitacek EJ, et al., (2007) Novel DNA Staining Method and Processing Technique for the Quantification of Undamaged Double-Stranded DNA in Epidermal Tissue Sections by PicoGreen Probe Staining and Microspectrophotometry. Journal of Histochemistry and Cytochemistry. 55: 999-1014

Membership in Professional Societies

Chemistry Societies:

  • American Institute of Chemists
  • Royal Society of Chemistry
  • American Institute of Chemical Engineering
  • American Chemical Society

Molecular Biology Societies:

  • American Society for Biochemistry and Molecular Biology
  • American Society for Cell Biology

Miscellaneous Societies:

  • American Medical Association
  • Histochemical Society
  • American Association of Pharmaceutical Scientists
  • American Association for the Advancement of Science
  • Nano Science and Technology Institute

Department of Life Sciences
Theobald Science Center

Old Westbury
Theobald Hall, Room 421
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The Life Sciences Department offers degrees at our campuses in New York City and Long Island, NY.