Assistant Professor of Chemistry
Department of Life Sciences
Edward Guiliano Global Center, office 405A
1855 Broadway, New York
B.A., Chemistry (Summa cum Laude), Whitman College, 2003
Ph.D., Physical Chemistry, Vanderbilt University, 2007
Post-Doc, Columbia University, 2007-2010
Ana G. Petrovic has joined the NYIT Life Science Department in 2010 after completing a three-year combined teaching and research postdoctoral fellowship at Columbia University in Department of Chemistry. Her overall research interest belongs to domain of Chiral Chemistry. It involves a combination of chiroptical spectroscopy and molecular modeling techniques to achieve reliable structural elucidations of chiral systems as well as to study chiral induction phenomena. Her research is accomplished through collaborative network with Columbia University and John Jay College of Criminal Justice.
Since joining the NYIT faculty, she has taught Physical Chemistry, Biochemistry, Engineering Chemistry, Foundations of Scientific Process (FCSC), and has functioned as the FCSC Course Coordinator. In teaching, she is taking an active role in enhancing science core curriculum pedagogy at NYIT.
Ana G. Petrovic's current research interest spans three projects:
A) Structural investigations of chiral organic, inorganic and biomolecules via tandem use of three chiroptical spectroscopic methods: Vibrational Circular Dichroism (VCD), Electronic Circular Dichroism (ECD), and Optical Rotatory Dispersion (ORD). Implementing these methods for reliable structural elucidation of chiral molecular systems is of a major scientific and economic interest due to repercussions of chirality on development of drugs, agrochemicals, food additives, fragrances, and catalysts.
Recent involvements in the domain of structural investigations of chiral molecules via chiroptical methods have focused on organophosphorus pesticides and natural products. This research project is a collaborative effort of NYIT, John Jay College and Columbia University.
B) Investigating scope, advantages and limitations of applying dimeric porphyrin tweezers as chirality probes for determining the absolute configuration of diamines and amino alcohols. This research is based on performing supramolecular host-guest complexation studies in tandem with ECD chiroptical investigations and molecular mechanics conformational searches.
The project is also a collaborative effort with her colleagues at Columbia University and John Jay College.
C) Exploring the phenomenon of supramolecular chirality induction on ladder-like molecular architectures. This effort could find utility in the realm of material science and information storage.
The ability to induce supramolecular chirality as well as to control the screw-sense and the degree of helicity plays a vital role in the frontier of biomolecular recognition, material science and information storage. Although helical-induction of single-strand helices has been performed in the past, for example, by covalently adhering enantiopure chiral additives to foldable polymers, the induction of double-strand helices is rare. The double-strand helical structures are frequently found in nature and are closely related to the physiological functions of biomolecules, such as nucleic acids (DNA, RNA, even PNA) and proteins. This research-plan reflects the interest in developing a novel, sensitive tool for helical-sense programming of double-stranded biomolecular architectures.
A list of recent publications:
Petrovic, Ana G.; Vantomme, G.; Negrón-Abril, Y. L.; Lubian, E.; Saielli, G.; Menegazzo, I.; Cordero, R.; Proni, G.; Nakanishi, K.; Carofiglio, T.; Berova, N. "Bulky melamine based Zn-porphyrin tweezer as a CD probe of molecular chirality". Chirality. 2011, Accepted & Published online: DOI: 10.1002/chir.21001.
Kpegba, K.; Agbonon, A.; Petrovic, A.G.; Amouzou, E.; Gbeassor, M.; Proni, G.; Nesnas, N. "Epiafzelechin from the Root Bark of Cassia sieberiana: Detection of DART Mass Spectrometry, Spectroscopic Characterization, and Antioxidant Properties." Journal of Natural Products. 2011, 74(3), 455-459.
Petrovic, Ana G.; Navarro-Vázquez, A.; Alonso-Gómez, J. L. "From Relative to Absolute Configuration of Complex Natural Products: Interplay between NMR, ECD, VCD, and ORD assisted by ab initio Calculations". Mini-Review in Current Organic Chemistry. 2010, 14(15), 1612-1628.
Rivera-Fuentes, Pablo; Alonso-Gómez, José Lorenzo; Petrovic, Ana G.; Santoro, Fabrizio; Harada, Nobuyuki; Berova, Nina; and Diederich, François. "Amplification of Chirality in Monodisperse, Enantiopure Alleno-Acetylenic Oligomers". Angewandte Chemie International Edition. 2010, 122, 1-6.
Petrovic, Ana G.; Chen, Y.; Pescitelli, G.; Berova, N. and Proni, G. "CD-sensitive Zn-porphyrin tweezer host-guest complexes. Part 1: MC/OPLS-2005 computational approach for predicting preferred intraporphyrin helicity". Chirality. 2010, 22(1), 129-139.