Gavin McStay received his Ph.D. from the University of Bristol, UK, with Professor Andrew Halestrap studying the molecular composition of the mitochondrial permeability transition pore involved in cell death. I performed post-doctoral research with Dr. Douglas Green at the La Jolla Institute for Allergy & Immunology in San Diego, Calif., and St. Jude Children's Research Hospital in Memphis, Tenn., studying apoptosis, especially the role of mitochondria and caspases. Following, this he worked with Professor Alexander Tzagoloff at Columbia University studying assembly of cytochrome oxidase in budding yeast before moving to NYIT. McStay is continuing these areas of research to gain an understanding of fundamental processes in cells with the hope that the findings can make an impact in biomedical and biotechnological research.
- Assembly of the mitochondrial electron transport chain
- The role of mitochondria in cell death
- Caspase activity and regulation
- McStay GP. Turnover of mitochondrial transporters and ion channels. Journal of Bioenergetics and Biomembranes (in press).
- McStay GP. Use of peptide-based substrates and inhibitors of apoptotic caspases. Methods in Molecular Biology 1419:57-67, 2016.
- McStay GP, Su C-H, Thomas SM*, Xu JT*, Tzagoloff A. Characterization of Assembly Intermediates Containing Subunit 1 of Yeast Cytochrome Oxidase. Journal of Biological Chemistry 288 (37): 26546-26556, 2013.
- McStay GP, Su C-H, Tzagoloff A. Modular Assembly of Yeast Cytochrome Oxidase. Molecular Biology of the Cell 24 (4): 440-452, 2013.
- McStay GP, Salvesen GS, Green DR. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death and Differentiation 15 (2): 322-331, 2008.
- Cell Biology
- General Biology
- Independent/Biomedical Research
Professional Honors & Awards
- Phi Eta Sigma Honorary member